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PGT-SR
Pre-implantation genetic testing for chromosomal structural rearrangements (PGT-SR) tests for issues with chromosomes of your embryos that might cause developmental defects or recurrent miscarriage.
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What is PGT-SR?
Pre-implantation genetic testing for chromosomal structural rearrangements screens embryos created during IVF for structural changes in the chromosomes. It can also test for aneuploidy - where an embryo has an extra or missing chromosome.
Chromosomes are the packages of DNA within the cells of our body. Changes like deletions, duplications or inversions can cause miscarriage or developmental defects in children that are born. These changes can be inherited or happen spontaneously.
PGT-SR can be used if you’re at high risk of passing on a structural rearrangement to your child or have experienced multiple miscarriages caused by chromosomal abnormality.
TFP Oxford Fertility is one of the selected IVF units that provides NHS England-funded PGT-SR treatment.
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How does PGT-SR work?
PGT-SR is carried out on embryos created during in vitro fertilisation (IVF).
A small sample of cells is taken from each embryo and sent off to an external lab in London where they are assessed for chromosomal abnormalities.
The embryos are frozen while we wait for the results of the biopsy. Any chromosomally normal embryos can be thawed ready for transfer or remain frozen until you're ready to use them.
Types of structural rearrangements
Inversion - One chromosome is affected where a segment is flipped upside down
Reciprocal translocation - Segments of genetic material are swapped between two chromosomes
Robertsonian translocation - Two chromosomes join together to create one long one, resulting in 45 chromosomes rather than 46
Structural rearrangements often result in extra or missing material in an embryo, called an unbalanced rearrangement. However, they can also be balanced. You can lead a perfectly healthy life with a balanced rearrangement, but your embryos are at risk of inheriting an unbalanced rearrangement when you conceive.
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What is the PGT-SR process?
If you require pre-implantation genetic testing during IVF, we'll carefully take a sample of cells from each of the embryos created which is then sent to the Cooper Genomics Laboratory in London to be tested by expert embryologists.
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Biospy
During IVF, we grow your embryos for 5-6 days until they develop into a blastocyst. An embryologist will remove a small sample of cells from the blastocyst using a thin needle.
Embryo freezing
Following the biopsy, your embryos are frozen and safely stored in a cryopreservation chamber whilst you await the results of the genetic testing.
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DNA testing
The DNA from the collected cells is tested to assess whether they are chromosomally normal.
This process takes around four weeks to complete.
Embryo transfer
After receiving the results of your pre-implantation genetic testing, any embryos that are not affected by genetic or chromosomal abnormalities are suitable for transfer. The highest quality embryo will be chosen so that you can continue your IVF cycle.
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How much does PGT-SR cost?
If you choose to have PGT-SR as part of your IVF treatment, this will incur an additional charge on top of your IVF cycle. The total cost will depend on the number of embryos being tested and whether any additional procedures are required.
You'll find a breakdown of PGT-SR pricing below.
*Medication required throughout treatment is charged separately. **Prices are subject to regional variation and may change over time.
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IVF
ÂŁ5,520
Includes egg retrieval and embryo transfer
PGT-SR
ÂŁ2,775
Including first embryo analysis and PGT-SR
PGT - 1st embryo
ÂŁ890
PGT-SR
ÂŁ1,885
Additional embryo analysis
ÂŁ510
Per embryo
PGT Thaw & refreeze
ÂŁ285
If required
Fertility counselling
As part of your treatment plan, you'll have access to a specialised fertility counsellor. They can help you understand the impact of any chromosomal abnormalities you may carry and the risks associated with passing these onto a child. We’re here to reassure you, answer your questions, and give you the emotional support you need every step of the way.
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Pre-implantation genetic testing FAQs
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